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AstraZeneca’s Respiratory & Immunology medical resource centre for healthcare professionals

Discover the latest advances and approaches in asthma, COPD and more

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Eosinophilic immune dysfunction

When eosinophils are at the core [1-4]

Eosinophilic immune dysfunction (EID) can be characterised as the dysregulation of biological mechanisms involved with eosinophil recruitment and activation [1]. By releasing toxic mediators and cytokines, eosinophils can act as effector cells and play a key role in the self-perpetuating cycle of inflammatory damage [2].


AstraZeneca is committed to uncovering eosinophilic immune dysfunction across a range of inflammatory diseases: eosinophilic asthma, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, eosinophilic granulomatosis with polyangiitis and hyper-eosinophilic syndrome.

Immune cells and immune mediators that interact with eosinophils

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