Eosinophilic immune dysfunction
When eosinophils are at the core [1-4]
Eosinophilic immune dysfunction (EID) can be characterised as the dysregulation of biological mechanisms involved with eosinophil recruitment and activation [1]. By releasing toxic mediators and cytokines, eosinophils can act as effector cells and play a key role in the self-perpetuating cycle of inflammatory damage [2].
AstraZeneca is committed to uncovering eosinophilic immune dysfunction across a range of inflammatory diseases: eosinophilic asthma, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, eosinophilic granulomatosis with polyangiitis and hyper-eosinophilic syndrome.
References
References:
[1] Ramirez GA, Yacoub M-R, Ripa M, et al. Biomed Res Int. 2018:9095275.
[2] Rothenberg ME, Hogan SP. Annu Rev Immunol. 2006;24:147-174.
[3] Rosenberg HF, Dyer KD, Foster PS. Nat Rev Immunol. 2013;13(1):9-22.
[4] Rosenberg HF, Dyer KD, Foster PS. Supplementary Appendix. Nat Rev Immunol. 2013;13(1):9-22.