Eosinophilic immune dysfunction
When eosinophils are at the core [1-4]
Eosinophilic immune dysfunction (EID) can be characterised as the dysregulation of biological mechanisms involved with eosinophil recruitment and activation . By releasing toxic mediators and cytokines, eosinophils can act as effector cells and play a key role in the self-perpetuating cycle of inflammatory damage .
AstraZeneca is committed to uncovering eosinophilic immune dysfunction across a range of inflammatory diseases: eosinophilic asthma, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, eosinophilic granulomatosis with polyangiitis and hyper-eosinophilic syndrome.