Eosinophilic immune dysfunction
When eosinophils are at the core [1-4]
Eosinophilic immune dysfunction (EID) can be characterised as the dysregulation of biological mechanisms involved with eosinophil recruitment and activation . By releasing toxic mediators and cytokines, eosinophils can act as effector cells and play a key role in the self-perpetuating cycle of inflammatory damage .
AstraZeneca is committed to uncovering eosinophilic immune dysfunction across a range of inflammatory diseases: eosinophilic asthma, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, eosinophilic granulomatosis with polyangiitis and hyper-eosinophilic syndrome.
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 Rosenberg HF, Dyer KD, Foster PS. Nat Rev Immunol. 2013;13(1):9-22.
 Rosenberg HF, Dyer KD, Foster PS. Supplementary Appendix. Nat Rev Immunol. 2013;13(1):9-22.