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AstraZeneca’s Respiratory & Immunology medical resource centre for healthcare professionals

Discover the latest advances and approaches in asthma, COPD and more

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TSLP in Severe Asthma – Understanding the Science

A look at the essential role of the epithelium and epithelial cytokines in health and disease


The airway epithelium is a common source of inflammation and a central factor in asthma pathology [1,2]. It is the first point of contact for viruses, allergens, pollutants, bacteria, physical injury and other external stimuli [1,2,3].


Thymic stromal lymphopoietin (TSLP), a key epithelial cytokine at the top end of the inflammatory cascade, offers a new way to think about severe asthma [1,2,3].


In this video, respiratory expert Dr Jonathan Corren discusses the essential role that the epithelium and TSLP play in severe asthma.

Expand your understanding of the fundamental role of the epithelium in asthma.

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