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AstraZeneca’s Respiratory & Immunology medical resource centre for healthcare professionals

Discover the latest advances and approaches in asthma, COPD and more

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In the crime of severe asthma… “TSLP Made Us Do It”

Thymic stromal lymphopoietin (TSLP), an epithelial cytokine, can be a real mastermind behind inflammation, giving orders for downstream effector cells to follow [1,2].

TSLP is an epithelial cytokine towards the top of the asthma inflammatory cascade that could offer a new way to think about severe asthma [1,2,3].

Much of the recent research into severe asthma has focused on the downstream mediators of airway inflammation. But perhaps it is time to examine the role of mediators at the top end of the inflammatory cascade…

Review the evidence to discover more about how TSLP can be a real mastermind behind inflammation [1,4].

Research has shown that TSLP can play a key role in both allergic inflammation, eosinophilic inflammation and potentially neutrophilic inflammation [1-4].

Look deeper to unearth the role of TSLP in severe asthma

Severe asthma inflammation cascade PDF download on the role of TSLP in severe asthma

Download the pathway to learn more

Severe asthma inflammation cascade PDF download on the role of TSLP in severe asthma

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