In the case of severe asthma… “Our orders came from the epithelium”
Much of the recent research into severe asthma has focused on the downstream mediators of airway inflammation. But perhaps it is time to examine the role of mediators at the top of the inflammatory cascade…
TSLP, IL-25 and IL-33, key epithelial cytokines, can be real masterminds behind inflammation, giving orders for downstream effector cells to follow [1, 2, 3].
Focusing on epithelial cytokines at the top of the inflammatory cascade offers a new way to think about severe asthma [1, 2, 3, 4].
Review the evidence to discover more about how epithelial cytokines can be real masterminds behind inflammation.
Epithelial cytokines such as TSLP, IL-23 and IL-33 can play a key role in allergic and eosinophilic inflammation [1, 2, 4, 5, 6, 7]. TSLP can also affect airway smooth muscle cells [4].
LOOK DEEPER TO UNEARTH THE ROLE OF EPITHELIAL CYTOKINES IN SEVERE ASTHMA
Click here to download a pdf of the role of epithelial cytokines and the airway epithelium in severe asthma inflammationDownload the pathway to learn more
References
References:
[1] Corren J. J Allergy Clin Immunol Pract. 2019;7(5):1394-1403.
[2] Li Y. J Immunol. 2018;200:2253-2262.
[3] Sy CB, Siracusa MC. Front Physiol. 2016;7:214.
[4] Gauvreau GM et al. Expert Opin Ther Targets. 2020;24(8):777-792.
[5] Liang Y et al. J Allergy Clin Immunol. 2019;144(4):1025-1035.e7.